Lead Discovery Strategies for Identification of Chlamydia pneumoniae Inhibitors
نویسندگان
چکیده
منابع مشابه
Lead Discovery Strategies for Identification of Chlamydia pneumoniae Inhibitors
Throughout its known history, the gram-negative bacterium Chlamydia pneumoniae has remained a challenging target for antibacterial chemotherapy and drug discovery. Owing to its well-known propensity for persistence and recent reports on antimicrobial resistence within closely related species, new approaches for targeting this ubiquitous human pathogen are urgently needed. In this review, we des...
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Both C. pneumoniae and M. pneumoniae are common causes of respiratory tract infection. At present, both are still diagnosed in the laboratory retrospectively by serology. This is despite many publications which indicate that PCR, which is not retrospective, is extremely good at detecting these organisms. We thought that a single PCR test which could detect both organisms simultaneously in a...
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no antibodies to brucella when tested 9 months later is evidence against a common source of infection. Brucellosis in domestic animals has not been recorded in Sweden since the 1950s, and human brucellosis acquired in this country has not been reported since then. The possibility of coital transmission of bmcella has long been suggested, but only recently has brucellosis been isolated from huma...
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A kinase-targeting cell-based high-throughput screen (HTS) against Trypanosoma brucei was recently reported, and this screening set included the Published Kinase Inhibitor Set (PKIS). From the PKIS was identified 53 compounds with pEC50 ≥ 6. Utilizing the published data available for the PKIS, a statistical analysis of these active antiparasitic compounds was performed, allowing identification ...
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ژورنال
عنوان ژورنال: Microorganisms
سال: 2016
ISSN: 2076-2607
DOI: 10.3390/microorganisms4040043